Senate Majority Leader: Any War with Iran Should Result in Regime Change

by | Feb 26, 2026

Senate Majority Leader: Any War with Iran Should Result in Regime Change

by | Feb 26, 2026

president donald trump and melania trump with senator john thune

Senate Majority Leader John Thune said that any strikes on Iran should be aimed at causing regime change in Tehran. 

“In my view, if you’re going to do something there, you better well make it about getting new leadership and regime change,” the Senator said on Thursday. “If you’re going to take some sort of action, I think you want to achieve a result that actually brings about the transformational change that I think we want in the region.”

Thune is among several Senators who have argued that Tehran is historically weak, and President Donald Trump should order an attack on Iran to cause regime change. “The Ayatollah lost to Israel in the 12-day war. They are weaker. The regime is weaker than it ever has been. And what I’ve urged the president, do not miss this opportunity,” Cruz told CNBC host Joe Kernen on Wednesday. “If the Ayatollah is removed from power, it will make America much safer.”

Trump is threatening to attack Iran if Tehran does not agree to a deal that severely restricts its civilian nuclear program in exchange for minimal sanctions relief. 

While Senators and administration officials have asserted that the US must attack Iran to prevent Tehran from obtaining a nuclear weapon, the Islamic Republic does not have a nuclear weapons program and is not currently enriching uranium. 

“The President, I don’t think, to my knowledge, has made any decisions, but I think they’re gaming out what contingencies might look like and what’s in our national security interests.” Thune added, “Of course, first and foremost is to prevent them from having a nuclear capability but there are also other threats that they represent in the region.”

Kyle Anzalone

Kyle Anzalone

Kyle Anzalone is news editor of the Libertarian Institute, opinion editor of Antiwar.com and co-host of Conflicts of Interest with Will Porter and Connor Freeman.

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